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Nevertheless, the physician who elects to use zyprexa for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient see dosage and administration .

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Olanzapine should be used with particular caution in patients with known cardiovascular diseasehistory of myocardial infarction or ischemiaheart failureor conduction abnormalitiescerebrovascular diseaseand conditions which would predispose patients to hypotensiondehydrationhypovolemiaand treatment with antihypertensive medicationswhere the occurrence of syncopeor hypotension and/or bradycardia might put the patient at increased medical risk.

Orthostatic hypotension with antihypertensivesalcoholcautiondiazepamCaution with other CNS drugsanticholinergicshepatotoxic agentsConcomitant IV benzodiazepinenot recommended with IM olanzapineMay antagonize levodopadopamine agonistsMay be antagonized by rifampinomeprazolecarbamazepineothers that induce CYP1A2 or glucuronyl transferaseMay be potentiated by fluvoxamineothers that inhibit CYP1A2Smokers may have increased clearance.

Patients should be advised regarding appropriate care in avoiding overheating and dehydrationPatients should be advised to call their doctor right away if they become severely ill and have some or all of these symptoms of dehydrationsweating too much or not at alldry mouthfeeling very hotfeeling thirstynot able to produce urinesee Warnings and Precautions5.13

When using Zyprexa and fluoxetine in combinationthe prescriber should also refer to the Warnings and Precautions section of the package insert for SymbyaxWhen using Zyprexa in combination with lithium or valproatethe prescriber should refer to the Warnings and Precautions sections of the package inserts for lithium or valproatesee Drug Interactions7

Some of your symptoms may improve with treatmentIf you do not think you are getting bettercall your doctor.

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with this new focus, the sales force for zyprexa were somehow convinced to tell doctors that fatigue is really the only side effect that presents itself with zyprexa use by their patients, which of course is false.

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