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Other acne products containing benzoyl peroxide, erythromycin or clindamycin may be used with differin but they must be applied in the morning and differin at night.

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Erythromycin inhibits the breakdown of HMG-CoA reductase inhibitorsstatinssuch as atorvastatinLipitorlovastatinMevacorand simvastatinZocorby the liver leading to increased levels of statins in the bloodHigh levels of statins could result in severe myopathymuscle damagewith rhabdomyolysisrrapid breakdown of skeletal musclethat may damage the kidneys or even lead to deathErythromycin also can elevate blood levels of some anti-seizure drugs such as carbamazepineTegretolby preventing the breakdown of the anti-seizure drug by the liverThereforedoses of the anti-seizure drugs may need to be reduced during treatment with erythromycinErythromycin also increases blood levels of sildenafilViagraThe dose of sildenafil should be reduced when treating with erythromycin.

Erythromycin is used in childrenoften to treat ear infections or chest infections.

Combining erythromycin with ergotamine or ydroergotamine has been associated with acute ergot toxicityThis combination should be avoided.

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be sure to mention any of the following amiodarone cordarone, pacerone ; certain antifungals such as itraconazole sporanox and ketoconazole nizoral ; aprepitant emend ; carbamazepine carbatrol, epitol, tegretol ; cimetidine tagamet ; clarithromycin biaxin ; cyclosporine neoral, sandimmune ; dexamethasone decadron, dexpak ; diltiazem cardizem, dilacor, tiazac, others ; erythromycin e.

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